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Baird dt(1), brown a, cheng l, critchley ho, lin s, narvekar n, williams ar. Basic information. Basu r(1), gundlach t, tasker m. Baulieu first discovered mifepristone (ru486) as part of a large research program on steroidal compounds with antihormone properties. Because follicular development is maintained, the endometrium is exposed to estrogen for prolonged periods unopposed by progesterone. Because of its slow removal rate from the circulation, mifepristone can be administered in a single oral dose (600 mg) for the termination of pregnancy. Because this hormone is blocked, the uterine lining begins to shed, the cervix begins to soften and bleeding may occur. Before prescribing mifeprex, inform the patient about the risk of these serious events; 8 jul 2019 mifepristone has potential also as a method of inducing labour in late pregnancy through its actions in antagonising progesterone, thus increasing uterine contractility and by increasing the sensitivity of the uterus to the actions of prostaglandins.

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